Neurology & Neuropathic Pain
Diabetic Peripheral Neuropathy & Nerve Compression
Neuropathic pain arises from progressive metabolic or mechanical damage to peripheral nerve axons and myelin sheaths, leading to severe shooting burning pain, allodynia, and numbness.
Primary Symptoms & Clinical Manifestations
- Burning sensation in feet & hands ('glove and stocking' distribution)
- Lancinating electric shock-like shooting pains
- Hyperalgesia and tactile allodynia (pain from light touch)
- Loss of vibratory perception and reflexes
Known Risk Factors & Predispositions
- •Longstanding poorly controlled blood glucose (HbA1c > 7.0%)
- •Microvascular oxidative stress and advanced glycation end-products (AGE)
- •Vitamin B12 and folate deficiency
- •Alcohol consumption and neurotoxic agents
Evidence-Based Management & Protocols
01.Targeted calcium alpha-2-delta ligand modulation (Pregabalin)
02.Descending monoaminergic pain pathway inhibition (Nortriptyline)
03.High-dose active neurological cobalamin remyelination therapy (Methylcobalamin)
04.Antioxidant and microvascular preservation with Benfotiamine & Alpha Lipoic Acid
Icon Drugs Treatment Options
Prenerve Caps
Pregabalin 75 mg + Methylcobalamin 750 mcg
Prescribing Specs
Prenerve-NT
Pregabalin 75 mg + Nortriptyline HCl 10 mg + Methylcobalamin 1500 mcg
Prescribing Specs
Prenerve Forte
Methylcobalamin 1500 mcg + Benfotiamine 15 mg + ALA 100 mg + Inositol 100 mg + B-Complex + Lutein
Prescribing Specs
Prenerve Inj
Mecobalamin 1500 mcg + Folic Acid 0.7 mg + Niacinamide 12 mg
Prescribing Specs
Treatment must only be prescribed by authorized healthcare providers following objective diagnostic assessment.